Workflow from Scientific Research

Main steps in the ancestral inference pipeline. The pipeline accepts individual genotype data (microarray or sequencing data) as input. The genotype data are phased and imputed against a phasing and imputation reference panel in first Phasing and Imputation stages, and painted against the painting reference panel including preclustered groupings (5 groups in this example; 127 in our actual analysis). In a final mixture fitting stage, non-negative coefficients summing to one and representing the proportions of ancestries from the labeled groups in the reference panel are inferred.

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