SASA values for each residue and the relative changes in RMSF in the -carbon among the protomer C of the EV71 pentamer, evaluating different protonation states with 2 wt % urea and without urea across a range of pH values. The purple stars denote stable-bound urea with RMSD less than 5 during the simulation and proximity to the residue of less than 6 . The results of all five protomers in the EV71 pentamer are inFigure S17.