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Analysis of optic nerves with markers of RGC axon integrity, stress, and inflammation demonstrated some significant but incomplete protection, as supported by unsupervised hierarchical clustering where 33% of treated nerves clustered with normal controls rather than untreated OHT demonstrating an overall protected profile (no untreated OHT nerves have a profile like NT nerves; HT-vehicle n= 6 ONs; OHT-vehicle n= 8 ONs; OHT-B6/B9/B12/choline n= 9 ONs). Also see Figure S2C.
#Heatmap#Clustered#Microscopy#Photo#Optic Nerves#RGC Axon Integrity#Stress#Inflammation#Neuroprotection#Hierarchical Clustering
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