Genes in these pathways are also differentially expressed (red,upregulated;blue,downregulated) in the DBA2/J mouse model of glaucoma (relative to control, D2-Gpnmb+), with an overall upregulation of the methionine cycle in the ONH and downregulation in the retina from early to late disease (for ONH, Early 1 [n= 8], Early 2 [n= 6], Mod [n= 4], and Sev [n= 4] where expression is compared ton= 5 D2-Gpnmb+; in the retina, Early 1 [n= 8], Early 2 [n= 9], and Sev [n= 10]; expression is compared ton= 8 D2-Gpnmb+).
