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Quantitative analyses showing the percentage of human BrdU+/Ins+double-positive cells in control grafts and in grafts obtained from mice treated with either 0.4 or 0.8 mg/kg of RSPO1. All data shown in (D) represent mean ± SEM of n= 4. Results were considered significant if p< 0.0001 (****), p< 0.001 (***), p< 0.01 (**), and p< 0.05 (*) following a one-way ANOVA.

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