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The screen failure was caused by an inability to ingest at least one complete meal per day and compromised general health and severely deteriorated general condition. The participant died during hospital admission from causes considered unrelated torhodesiensehuman African trypanosomiasis and fexinidazole. For more information, seeappendix 1 (p 13). The participant had a relapse (confirmed by the presence of trypanosomes in the cerebrospinal fluid) and was successfully treated with melarsoprol. For more information, seeappendix 1 (p 13).

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