Protein Structure from Scientific Research

Distribution of disease-causing missense mutations in human MCT8, shown as the corresponding amino acids on human MCT10. Residues colored in yellow likely have a direct effect on cargo transport in MCT10 and MCT8, while residues colored dark blue are more likely to have indirect effects on either the shape of the pocket or the movement of helix bundles. Residues colored purple are likely affecting the protein by altering the chemical environment, for example from a hydrophobic to polar milieu.

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