Chemical Structure from Scientific Research
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Geometrical arrangements of Pitstop 2c (B) and Pitstop 2d (E) within their binding pocket on the clathrin TD are shown. Meshes represent 2|Fo| - |Fc| omit electron density maps, contoured at 1.0 sigma, where the ligand was excluded during map calculation. Pitstop 2c adopts a U-shape, whereas Pitstop 2d is in an extended conformation.
#Chemical Structure#Pitstop 2c#Pitstop 2d#Clathrin Terminal Domain#Binding Pocket#Electron Density Maps#Ligand#U-Shape Conformation#Extended Conformation
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