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Crystal structure of clathrin TD in complex with Pitstop 2 in orange (left; PDB:4g55) at 1.69 A resolution is superimposed onto clathrin in complex with a beta-arrestin-derived in cyan (PDB:1C9I) at 2.93 A resolution (right), illustrating the overall binding mode and spatial interaction context for the design of second-generation derivatives. Hot-spot residues essential for Pitstop 2 and arrestin-derived peptide-protein interactions within the clathrin box are labeled. See also Tables S1S3.

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