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Cytoscape string analysis of K--GG peptides that are significantly increased upon compound39treatment in CCCP-treated HEK293 USP30-APEX2 cells in the labeled ubiquitome (E) and proximal ubiquitome (F). Circle size is proportional to the log2difference in K--GG peptide intensity +/- compound39treatment, with the largest difference used if multiple peptides originate from the same protein. Red circles denote OMM, and blue circles denote other mitochondrially localized Mitocarta 3.0-annotated proteins. Cytoscape String network based on string confidence score cutoff 0.7. Edge width is proportional to string confidence score.42,46

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