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Western blot and (H) quantification of the phosphorylated to total ERK1/ERK2 ratio in i3N GA-HiBiT neurons after 6 days of treatment with the MEK1/2 inhibitor trametinib (0, 0.01, 0.1, 1 μM), followed by an additional 3 days in combination with either DMSO or the EC50dose of periplocin (***p≤ 0.001, one-way ANOVA,N= 3 inductions).

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