Top panel, histogram of beta values for cg00618323 in 645 TCGA tumors analyzed by Illumina 450 K beadchips. cg20898288 is not present on this array. A cut-off of 0.4 was used define hypomethylation and hypermethylation as the TCGA data was corrected for tumor cell content, thereby removing a considerable impact of normal cell contamination as seen in the beta histogram. Bottom panel: corresponding CpG beta value heatmap for the 645 TCGA tumors.
