Sleep following single bouts of social defeat stress (4 sessions in 1 h) is associated with a reduction of anxiety, as indicated by the performance of mice in the open-arm maze. If mice are sleep deprived after social defeat stress, they are anxious. (Mice that venture out less into the open arms are assumed to be anxious). Redrawn from data and concepts in Yu et al.51and Feng et al.61SD, sleep deprivation.