Cell-type probability trajectories from a three-state ontogeny model in which EMBs differentiate to HSCs or MPPs, followed by HSC-to-MPP or MPP-to-HSC transitions. The displayed trajectories for 30-month (right) and 3-month (left) donors are based on iterating the hidden Markov model starting at EMB. Thickness of arrows reflect the proportion of overall transitions between states; transition rates are derived in Supplementary Note 2.
