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Quantification of GluA4 and PV colocalization intensity in L2/3 and L5/6 of V1 (4 mice per genotype, each dot = single animal). There was a significant reduction in colocalization intensity in L5/6, but not L2/3, in APP/PS1 compared with WT mice (two-way ANOVA: genotype: F(1,12)= 16.4,p =0.0016; layer: F(1,12)= 1.04,p =0.372; genotype× layer: F(1,12)= 19.37,p =0.0009).
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