Alpha- and beta-diversity indices and relative abundances of bacterial species in the ileal microbiota from young mice treated as illustrated inFigure 3D by shotgun metagenomic sequencing. Statistics in the stacked bar graph show comparisons between the CD3 + vehicle group and the CD3 + EP4 antagonist group. Numbers in brackets indicate group sizes. Each dot represents one mouse. Significance is indicated as*p< 0.05,**p< 0.01,***p< 0.001,****p< 0.0001, or ns (not significant).