Microscopy from Scientific Research

Representative hippocampal neurons of rNLS8 mice with or without 4-week hTDP-43ΔNLSinduction, stained for hTDP-43ΔNLSand ataxin-2 for stress granules. Rows 1–4 represent control mice without hTDP-43ΔNLSexpression, unaffected neurons lacking hTDP-43ΔNLSaggregates with hTDP-43ΔNLSexpression, affected neurons with hTDP-43ΔNLSpuncta strongly colocalizing with stress granules, and affected neurons with hTDP-43ΔNLSpuncta partially demixed from stress granules, respectively. Scale bar, 10 and 2 μm for confocal and zoomed-in images, respectively.

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