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Schematic of the rNLS8 mouse model. hTDP-43ΔNLSexpression was induced starting at 5 weeks after birth (week 0, induction), and the hippocampus with 4-week induction was processed for antibody staining and imaging (week + 4, imaging). Mice typically reach end-stage after 11 weeks of induction (>week + 11, end).

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