Schematic of TDP-43 (1–414 aa) showing key domains. NTD, 1–80 aa; RRM1, 106–176 aa; RRM2, 191–262 aa; CTD, 263–414 aa; G, glycine-rich, 274–314 aa; HP, hydrophobic patch region, 318–343 aa; Q/N, Q and N-rich, 344–365 aa; S, serine-rich, 370–402 aa. Point mutations studied in subsequent sections are also indicated.
