The flexibility of TM6 and TM7 of P2Y2R in the self-activated state (labeled as ‘apo’) and the ATP-bound fully activated state (labeled as ‘ATP’) is quantified by MD simulations. The RMSF values of residues from K240 6.30 to C300 7.47 are shown, with the ECL3 region (residues S270–S277) highlighted by black dashed lines.
