Protein Structure from Scientific Research

Comparison of the ligand-binding pockets of four P2YRs: P2Y1R (PDB: 7XXH), P2Y2R (this study), P2Y4R (this study), and P2Y12R (PDB: 7XXI). The ligands bound to each receptor are depicted as follows: 2MeSADP (pink) for P2Y1R and P2Y12R, ATP (green) for P2Y2R, and UTP (purple) for P2Y4R. A black dashed line drawn from the bottom of ligand-binding pocket of P2Y2R serves as a reference to compare the depth of the ligand-binding pockets of different P2YRs.

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