Protein Structure from Scientific Research

Structural superposition of the ATP-bound P2Y2R–Gq–Nb35 and UTP-bound P2Y4R–Gq–Nb35 complexes. The receptors from the two structures are aligned and displayed. Other subunits are omitted for clarity. P2Y2R is colored in blue, and P2Y4R is in gray. Conformational changes of TM1 and ICL1 are indicated by red arrows, and the two disulfide bonds are highlighted within a red dashed circle.

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