Genetic correlation between AOW and physical health (purple), cognitive traits (blue), neurodevelopmental conditions and psychiatric disorders (orange), cortical phenotypes (grey) and non-preregistered motor phenotypes (green). Data are presented as correlation coefficients 95% CIs. Filled circles indicate significant correlations based on CIs. Filled squares indicate the traits that remain significantly genetically correlated with age at onset of walking after adjusting the two-sided P values obtained from LDSC for multiple testing using Bonferroni correction. The maximum GWAS sample sizes for each of the traits included in the LDSC analysis are as follows: age at onset of walking N = 70,560; childhood BMI N = 61,111; birth weight N = 42,212; adult BMI N = 795,640; educational attainment N = 765,283; cognitive performance N = 269,867; autism N cases = 18,382, N controls = 27,969; ADHD N cases = 38,691, N controls = 186,843; schizophrenia N cases = 67,390, N controls = 94,015; cross-disorders N cases = 232,964, N controls = 494,162,; major depression N cases = 170,756, N controls = 329,443; bipolar disorder N cases = 41,917, N controls = 371,549; cortical phenotypes (fractional anisotropy, mean diffusivity, intracellular volume fraction, orientation dispersion index, isotropic volume fraction, cortical thickness, folding index, Gaussian curvature, intrinsic curvature index, local gyrification index, mean curvature, cortical surface area, grey matter volume) N = 36,663; muscle weakness in the pincer grip N cases = 48,596, N controls = 207,927; self-reported walking pace N = 450,967; early motor coordination N = 31,797; Parkinsons disease N cases = 26,421, N controls = 442,271.
