Venn Diagram from Scientific Research

Venn diagrams representing MiXeR bivariate analyses between AOW and the 6 other phenotypes with which it has Bonferroni-significant genetic correlations. The size of the circles and the numbers within them represent the relative polygenicity of each trait (that is, how many genetic variants contribute to 90% of the SNP heritability). The overlap between each pair of circles represents the degree of genetic overlap between the two phenotypes, that is, the number of shared variants in thousands, along with the standard error. Numbers and standard errors in sections of the circles that do not overlap represent the number of variants unique to that phenotype. The corresponding r g , estimated using LDSC, is shown below each Venn diagram.

DOI