I CAG calculated for the tail, cortex and striatum isolated from 12- and 24-week-old Htt . Q111 mice treated with AAV9-CBE, or controls. Data are shown as box plots, with each data point representing an independent animal (12 weeks, control group: tail n = 8, striatum n = 8; cortex n = 4; 12 weeks, CBE group: cortex n = 6, striatum n = 6, tail n = 5; 24 weeks, control group: tail n = 8, cortex n = 8, striatum n = 7; 24 weeks, CBE group: all tissues n = 7). The horizontal line marks the median, and whiskers denote the minimum and maximum values. * P = 0.0265, ** P = 0.0064, *** P = 0.0009, Welch’s one-tailed t -test.
