Histopathological scoring of pig skin with no treatment and with MNPs loaded with polymer only, PMMA microparticles and QDPMMA microparticles; n = 46 MNPs per group, six slides per MNP. (Untreated skin and QDPMMA MNPs had n = 5 biological replicates; the blank PMMA MNP and polymer-only MNP had n = 4 biological replicates; six tissue samples per biological replicate, s.d.)