Scatter Plot from Scientific Research

Top 20 groups of brain cell types ( n = 35 total tested) enriched with OCD GWAS signal using MAGMA. Dots represent log 10 ( P values) from MAGMA gene set enrichment tests of individual neuronal cell types from Zeisel et al. 30 . Vertical crosses represent the mean log 10 ( P value) observed for each brain cell type group. Blue crosses represent a significant enrichment of OCD GWAS signals (FDR across 35 groups, FDR < 0.05), while pink crosses indicate nonsignificant enrichment. Gray points represent the association ( log 10 ( P value)) for each single cell cluster (level 5 analysis defined by Zeisel et al. 30 ) in a given cell type (for example, excitatory neurons, cerebral cortex). CCK, cholecystokinin-expressing; R-LM, stratum radiatum-stratum lacunosum-moleculare.

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