Manhattan plot of long COVID after test-verified SARS-CoV-2 infection (strict case definition, n = 3,018) compared to all other individuals in each dataset (population controls, broad control definition, n = 994,582). A genome-wide significant association with long COVID was found in the chromosome 6, upstream of the FOXP4 gene (chr6: 41,515,652 G:C, GRCh38, rs9367106 , as the lead variant; P = 1.76 x 10 - 10 , Bonferroni P = 7.06 x 10 - 10 , increased risk with the C allele, OR = 1.63, 95% CI = 1.40–1.89). Horizontal lines indicate genome-wide significance thresholds for IVW meta-analysis before ( P < 5 x 10 - 8 , dashed line) and after (1.25 x 10 - 8 ) Bonferroni correction over the four long COVID meta-analyses (INCMNSZ = MexGen-COVID Initiative).
