Network from Scientific Research

Simplified network of validated brain interactions for SCZ-related genes ( Methods ). Circular and hexagonal nodes were prey and bait proteins in the pulldown studies, respectively. Nodes are colored as GWAS variants (green), drug targets (red), associated with SCZ in mice (blue) or other (gray). Gray edges were predicted from association scores in the brain and validated through pulldown experiments. Yellow edges are known interactors (physical associations in STRING; scores > 750). Purple edges have ipTM scores > 0.5. Purple labels annotate subgraphs of known interactors with the most enriched GO cellular components (exponent of BH-adjusted P value between brackets, according to a one-sided Fisher exact test).

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