Dendrograms of the 15 most brain-specific GWAS traits (left) and the 15 GO cellular components having the most brain-specific relationship with OCD (L2G ≥ 0.5; right). Dendrograms were constructed with complete-linkage clustering using the Manhattan distance on the relationship scores between traits (left) or between cellular components (right). Heat maps show genes overlapping between cellular components and OCD (orange; Jaccard index) or the enrichment of nonoverlapping genes from cellular components with drug targets, genes associated with OCD in mice or genes less confidently linked to OCD through GWAS (purple–green; conditional log 2 odds ratios of one-sided Fisher exact test; dots show BH-adjusted P values < 0.05; Methods ). SV, synaptic vesicle; CCV, clathrin-coated vesicle; m., membrane; SC, Schaffer collateral; ASD, autism spectrum disorder.
