UMAP from Scientific Research

Top: UMAP of CRISPRa cells colored by pseudotime and overlaid with contour lines indicating the location of NR4A2-OE (dashed lines) and control (solid lines) cells from day 12 to 18. Bottom left: bar plot depicting the fraction of control, NR4A2-OE, SOX17-OE and GATA2-OE cells in the two day 18 subpopulations. Bottom right: UMAP representation of GRNs inferred for day 18 of the CRISPRa screen. GRN TFs are colored by the log 2 fold change in regulon AUCell score between the NR4A2-OE and control groups. Shape corresponds to the day of highest regulon AUCell score.

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