Chemical Structure from Scientific Research

PictetSpengler reaction between Trp 1 and propionaldehyde 2. Interactions with Trp are defined from the sum of (ppb) for all the protons pointing to the -face (H1, H3, H4, H5 and H6 for 4merIIIV and H1, H3, H5 and H6 for 4merV ): weak <20 ppb, strong 20 ppb). b The reaction yield was monitored by 1 H NMR. c Variations from standard condition: reaction time 168 h, 2 (0.3 mmol). d Optimized condition: 4merIV (20%), 72 h, 37 C, 2 (0.3 mmol).

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