Electrode localizations from subjects in the current study, with blue representing VIM patients and orange representing STN patients. The bottom plot shows a positive Spearman correlation (two-sided) between relative clinical improvement (measured as ratios of the maximum achievable score for UPDRS-III tremor scores or FTM) following DBS and each DBS electrode’s connectivity to the lesion network map. A cohort regressor was applied to control for potential confounding effects related to differences between patient groups. No adjustment for multiple comparisons was applied. The shaded area indicates the 95% confidence interval. The red circle highlights an example of a volume of activated tissue (VTA) with low connectivity, shown alongside an example with high connectivity (green circle) to the lesion network map in ( C ). Transversal and coronal slices from the BigBrain atlas were used 61 . Cerebellar flatmaps were created using the SUIT toolbox 62 . DBS Deep Brain Stimulation, FTM Fahn-Tolosa-Marin Tremor Rating Scale, GPi Globus pallidus internus, STN Subthalamic nucleus, UPDRS-III Unified Parkinson’s Disease Rating Scale, part III, VIM Ventral intermediate nucleus of the thalamus.
