Comparison between experimental data (red dot, bulged ( N =11) samples; blue dots, budded ( N = 28) samples; all data presented as mean s.d.) and predicted phase diagrams of crypt morphology as a function of tension asymmetry and normalized volume v . Tension asymmetry of budded organoids agrees with the prediction considering crypt mechanosensation (right) rather than that without mechanosensation (left; see also Fig. 2f ).
