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Schematic diagram summarizing the potential mechanisms by which liver dysfunction affects IE deterioration. Pearson’s two-sided χ² test was used for figures ( A and M ); two-sided Pearson’s correlation (WGCNA-derived) for ( B and C ); and two-sided Spearman’s correlation for ( G , N – R ), with p -values adjusted for FDR (* p < 0.05, ** p < 0.01, *** p < 0.001). For ( F , H , and J ), unpaired two-sided Wilcoxon tests were used to compare NYHA class IV ( n = 60) with NYHA class II and III ( n = 134). Source data are provided as Source Data files.
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