Boxplots showing PhastCons conservation scores across three ctenophore species ( B. microptera , P. bachei and H. californensis ). The boxplot limits indicate the interquartile range (IQR), with the median as the middle line and whiskers extending to 1.5 IQR. Two-sided Wilcoxon rank sum test showed significant conservation differences between intergenic enhancers ( n = 969) and promoters in loops ( n = 778) (*** P = 1.3 x 10 -15 ) and between promoters in loops and promoters outside loops ( n = 14,996) (*** P < 2.22 x 10 -16 ), whereas intergenic enhancers and promoters outside loops showed no significant difference (not significant (NS), P = 0.88).
