Syntenic conservation within M. leidyi chromatin loops compared to H. californensis . Left plot, barplot showing the fraction of conserved orthologues (OGs) in all alignable genomic regions across ctenophore species (*** P = 5.5 x 10 -4 , chi-squared test for given probabilities). Right plot, boxplot of shared orthologues between individual genomic regions within chromatin loops ( n = 115) versus in random genomic regions ( n = 259) of similar size (*** P = 2.4 x 10 -5 , Wilcoxon rank sum test with continuity correction). Boxplot limits as in g . Silhouette of H. californensis in h reproduced from PhyloPic ( https://www.phylopic.org/ ), created by S. Haddock and K. Wothe under a CC0 1.0 Universal Public Domain licence.