Scatter plot relating donor age (f) and the presence of GMPs (g) to the number of clones identified by EPI-Clone in the TBM cohort and CD34 + cohort, respectively. P value calculated with a two-sided t -test computed from a generalized linear model of the Poisson family, using the number of cells observed as a weight. Dot size denotes the number of cells analysed (see b for a scale).