Bar Plot from Scientific Research

Key genomic events identified in pretreatment GBM. Segment-level copy number profile across chromosomes includes amplifications in red (copy number > 2.5) and deletions in blue (copy number < 1.5). Copy number-neutral regions are shown in black. For copy number, the y axis is shown in pseudo-logarithmic scale. Somatic mutations (magenta) and rearrangements (dark green) of potential clinical significance or in known cancer genes are included in the genomic region where each gene resides together with their allele fraction (AF). All events were identified based on the WGS of the pretreatment (day 4) tumor specimen, except for the EGFR (R108K) mutation identified based on the WGS of the resection (posttreatment; day +13) specimen.

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