pERK1/2-ERK, pMEK1/2-MEK1/2 levels in paired skin biopsies dose expansion Cohort 13: binimetinib 30 mg BD 1 - 21 d and crizotinib 250 mg O.D continuously. Right: Densitometry was performed on the WB images using ImageJ software. SC = screening. C1D15: Skin biopsy obtained between 3–6 h following morning dose of binimetinib.
