Benchmarking analysis of MethyLYZR prediction time on our Nanopore runs using the model trained on the 91 CNS and three metastasis tumor classes executed on an Apple iMac Pro (3 GHz 10-Core Intel Xeon W, 64 GB 2,666 MHz DDR4 RAM, 1 TB APFS SSD, Radeon Pro Vega 56 GPU with 8 GB VRAM, macOS 13.2.1). For data acquired from 15 min of sequencing, the runtime is negligibly small (on average less than 1 s), and, even with full 72-h runs, the prediction time remains well below 4 min, even in the most extreme cases (on average less than 1 min). Numbers on top state the mean number of CpGs for each time benchmarked. The bar represents the median, and the error bar is the s.d. gDNA, genomic DNA.
