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HNSCC (mEERL) bilateral tumor-bearing C57Bl/6 mice (n = 9–10/treatment group) were treated with RT (8 Gy 1X), CPH:SA IL-1alpha-MPs (IL-1alphaMPs) or their combination. Equivalent doses of Blank MPs were administered to Sham mice as a control. RT was administered to the irradiated tumor on Treatment Day 1 followed by two doses of CPH:SA IL-1alpha-MPs (equivalent to 7.5 ug rIL-1alpha in 18.75 mg MPs/ dose) intraperitoneally on Treatment days 2 and 10.

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