Manhattan plots showing associations between cis variants and regions with circulating protein levels, after adjusting for associated common variants and all coding variants of the cognate gene. The x axis represents genomic position and the y axis shows -log 10 P two-sided for our cis results across all proteins, split into single variants. The red lines represent Bonferronis significance thresholds (P <= 2.95 x 10 -10 for single variants and P <= 8.71 x 10 -9 for aggregate tests). P values are derived from two-sided tests from mixed linear models.
