Illustration from Scientific Research

The top 4 CC pairs between tumor and immune cells showing the highest spatial overlap represented by the J local score were visualized. The CCs from the tumor (yellow), immune cells (blue), and intersecting subregions (green) were visualized on the grid. The set-based Jaccard indexes were computed for each CC pair (J local ). Overall, STopover was superior to the conventional threshold-based method in capturing locally active subregions where tumor cell activity is low but immune cell activity is high (Region B).

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