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Activity of NUDT1 purine nucleoside triphosphate hydrolase converting reactive oxygen species (ROS)-damaged oxidized purine nucleotides to their corresponding monophosphates as exemplary depicted for 8-oxo-dGTP. Also N6-methyl-(d)ATP nucleotides are substrates of NUDT1 resulting in N6-methyl-(d)AMP, that is substrate of the adenosine deaminase-like protein ADAL1 converting the methylated nucleoside monophosphate to (d)IMP.
#Workflow#Chemical Structure#Illustration#NUDT1#ADAL1#Purine Nucleoside Triphosphate Hydrolase#Reactive Oxygen Species#Oxidized Purine Nucleotides#N6-methyl-(d)ATP#Adenosine Deaminase-Like Protein
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