Quantification of parenchymal CD11b+CD15+CD14−HLA-DR−LOX1+ (PMN-MDSC) cells as a proportion of total myeloid cells (CD11b+ cells) (left), between pre- (screening) and post treatment (C2D16) of 23 paired biopsies as determined by IHC. Right, parenchymal PMN-MDSC cell numbers in patients with at least 1 PMN-MDSC per cell/mm2(N= 18).pvalues are non-adjusted and are determined by paired two-sided Wilcoxon test. The boxplots in (C), (D), and (E) show the data distribution, where the line denotes the median, the box edges show the interquartile range, and each dot is one patient.
