Single-cell analysis of HCC samples. The left panels show UMAP plots of 185,469 live cells in six scRNA-seq datasets annotated by the CellTypist program with the healthy liver (upper) and immune cell (lower) models. The upper right panel shows UMAP plot of 31,794 hepatocytes with enrichment scores for the glycolytic pathway estimated by the ssGSEA program. The lower left panel presents the cytotoxic T cell/Treg cell ratio in the glycolysis-high and -low HCC groups (N= 28 and 28, respectively). Boxes represent the 25th, 50th, and 75th percentiles. Data are the mean ± SD. n.s, not significant; *p< 0.05, **p< 0.01, ***p< 0.001.
