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Simplified illustration of the mechanism of action of different cell death inhibitors. Z-VAD-FMK is a pan caspase inhibitor that irreversibly blocks apoptosis. Y-27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK) involved in cell dissociation-induced anoikis. Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis. Chloroquine. (CQ) prevents autophagosome formation during autophagy process. The iron chelator deferoxamine (DFO) is a ferroptosis inhibitor by preventing iron accumulation.

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