Features of genetic circuits within engineered cells. Switchability: activation of the circuit exclusively in the presence of a stimulus. Tunability: level of response according to the inducer concentration. Reversibility: capacity to return to the basal level following the removal of an inducer. Orthogonality: an exclusive response to the specifically designed inducer with a lack of interaction or interference with other stimuli. Kinetics of response: fast (in minutes) or slow (in hours) upon stimulation.
