Bar Plot from Scientific Research

Mean currents elicited by membrane stretch (bottom traces) and recorded in the cell-attached configuration at -80 mV in BMDMs polarized to M1. BMDMs M0 cells were first polarized to M1 in complete medium supplemented with LPS (10 ng/mL) and IFN-γ (20 ng/mL) cocktail for 24 h, and then treated with either EtOH (black traces) or 10 μM 7-KC (in red) for an additional 24 h in LDL-free medium. Left inset: M1 polarization was confirmed byTNFαgene expression and is represented as relative expression toTOP1. Right inset: peak current amplitude in EtOH (in black) or 7-KC (in red) condition, comparing WT and KO macrophages.

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